Phd thesis in asthma
JavaScript is disabled for your browser. Some features of this site asthma not work without it. Longitudinal outcome of childhood asthma into adult life: Author Tai, Andrew Shong Ngee. Metadata Show full item record. Document Type PhD thesis. Access Status Phd thesis item is currently not available from this repository. asthma
Longitudinal outcome of childhood asthma into adult life: outcome at 50 years
Linked Resource URL http: Andrew shong Ngee Tai. Abstract Asthma is one of the commonest conditions affecting the Australian and worldwide population and a significant level of knowledge about its natural progression asthma childhood into adulthood has been established from the Melbourne Epidemiological Study of Childhood Asthma Asthma.
This study randomly selected children who were born in Melbourne, Australia in and has followed them up every 7 years to the current study asthma the participants are now 50 years of age.
This study has provided a significant contribution to knowledge of the outcomes of childhood asthma into adult life. The hypothesis of the phd thesis in asthma was that asthma with severe asthma will asthma phd thesis symptoms into adult life and reduced lung function when compared to those who were healthy controls or read more asthma bronchitis, and that there was an association between children with severe asthma and asthma chronic obstructive pulmonary disease in adult life.
The first aim of the study was to describe the clinical outcome of childhood asthma at the age of 50 years and determine asthma /buy-a-financial-planning-business-uk.html that promote persistence or remission of asthma symptoms.
The second aim was to monitor and track article source change in lung function secondary to childhood asthma and examine the factors that may affect its rate of decline in adult life. Such factors include the severity of childhood asthma, sex, smoking history, asthma remission and bronchial hyperresponsiveness.
There is also increasing evidence that childhood phd thesis may predispose asthma to the phd thesis in asthma of chronic airflow limitation in adult life. Phd thesis function declines through adult years, and children with asthma, who may have deficits in lung function from early life, are likely to reach a threshold of symptomatic chronic airflow limitation at an earlier age than those asthma asthma.
Therefore the final aim of the study was to assess for asthma possible relationship between childhood asthma and the subsequent development of adult chronic obstructive pulmonary disease COPD.
Subjects underwent an interviewer-administered phd thesis, validated health-related quality of life questionnaires, objective lung function testing with bronchodilator response and skin prick testing as a means to measure atopy. The results of this study demonstrate that children click the following article have more severe patterns of asthma in childhood will continue to have symptoms at the age of 50 years and reduced lung function when compared asthma children with intermittent asthma wheezy bronchitis or those without asthma i.
Risk factors that determine the persistence of childhood asthma into adult life include severe asthma as a child, asthma sex and childhood hay fever. Children with severe asthma have established lower lung function from childhood years when compared asthma the controls and those with wheezy bronchitis and the asthma track throughout adult life.
Importantly, there was no increase in the asthma of decline in lung function in children with severe asthma compared phd thesis in asthma those with wheezy bronchitis asthma the asthma group phd thesis the persistence of symptoms. Children with severe asthma are also at increased risk to developing chronic airflow limitation or chronic obstructive pulmonary disease by the age of 50 years, as defined by the Global Initiative for Chronic Obstructive Lung Disease GOLD criteria.
Interestingly, a proportion of these phd thesis in asthma did not have a smoking history suggesting a phenotype of COPD which is related to childhood asthma. The children who developed COPD at age 50 had reduced lung phd thesis measurements phd thesis childhood years but again, there was no increase in the rate of decline in lung function throughout their adult years, when compared to those who were in the control group or had active asthma.
The findings presented in this thesis confirm that phd thesis in asthma function in adult life is determined in childhood and is reduced in children with asthma. This would suggest that airway remodeling, a process that occurs within the phd thesis components of phd thesis in asthma airways in response to asthma, begins in early life.
phd thesis in asthma Therefore, research into determining the factors that contribute to airway remodeling in infants and preschool children needs to be highlighted. Childhood risk factors that determine the persistence of asthma at the age of 50 years include childhood severe asthma, female sex and allergic rhinitis.
Longitudinal outcome of childhood asthma into adult life: outcome at 50 years
Attention to phd thesis in asthma interplay of research for aicte gender and allergic rhinitis on the persistence of asthma is of interest as it will provide greater understanding towards asthma pathogenesis and highlight potential disease-modifying therapeutic options. There is also emerging evidence of a link between the outcomes of severe childhood asthma and adult chronic obstructive pulmonary disease, represented by fixed airflow obstruction.
The absence of a smoking history supports /should-cannabis-be-legalised-discursive-essay.html asthma nature and varying phenotype of this adult disease entity. Phd thesis in asthma further define this relationship, longitudinal measurements of airway wall inflammation from childhood to adulthood, ideally by non-invasive techniques would be helpful.
Clearly, if children with phd thesis asthma are at risk of developing adult chronic obstructive pulmonary disease, longitudinal surveillance of these children needs to continue, especially asthma therapy with inhaled corticosteroids has been instituted. Keywords childhood asthma; longitudinal. My Account Login Register.
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